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Search Results for " endothelial cell adhesion molecule "

Targets Recommended: Integrin

6

抑制剂 & 化合物

1

天然产物

24

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4435	E7820 ER68203-00	Integrin	Cytoskeletal Signaling
	E7820 (ER68203-00) 是具有口服活性芳香族磺酰胺衍生物，是一种血管生成抑制剂，可抑制内皮上整合素 α2 亚基的表达。它调节 α1，α2，α3 和 α5 整联素 mRNA 表达，具有抗血管生成和抗肿瘤活性。它抑制大鼠主动脉血管生成，IC50为 0.11 μg/ml。
T67749	Fuzapladib IS-741	Phospholipase	Metabolism
	Fuzapladib (IS-741) (IS-741)是一种磷脂酶A2抑制剂，可以抑制细胞粘附分子Mac-1的表达。fuzpladib 阻断炎症细胞表面表达的粘附分子(integrin)的激活，阻止炎症细胞粘附血管内皮细胞和浸润组织，控制胰腺炎的恶化。
T70211	CAM741
	CAM741 is a novel selective inhibitor of vascular cell adhesion molecule 1 (VCAM1) synthesis in endothelial cells, blocking the process of cotranslational translocation, which is dependent on the signal peptide of VCAM1.
T76254	CD31
	CD31 (PECAM-1)，一种血小板内皮细胞粘附分子（platelet endothelial cell adhesion molecule-1），兼作产气荚膜梭菌b-Toxin (CPB) 的特异性内皮细胞受体。同时，CD31为ER-MP12抗原，桥接机械应力、代谢与炎症。其肽通过维持CD31 ITIM686与SHP2的磷酸化，抑制TCR诱导的T细胞激活。
T76254L	CD31 TFA
	CD31 TFA（PECAM-1），血小板内皮细胞粘附分子（platelet endothelial cell adhesion molecule-1），是产气荚膜梭菌b-Toxin (CPB)内皮细胞特异性受体，亦为ER-MP12抗原，链接机械应力、代谢与炎症。该肽通过维持CD31 TFA ITIM686与SHP2的磷酸化，抑制TCR诱导的T细胞活化。
T83680	Azurin (50-77) (P. aeruginosa) TFA Azurin p28,p28
	Azurin (50-77)是一种含铜细菌蛋白azurin的肽段，存在于P. aeruginosa中，具有细胞周期停滞、抑制癌细胞增殖和调节血管生成活性。作为VEGFR2的抑制剂（IC20约为10.7 µM），Azurin (50-77)（20 µM）能在MCF-7乳腺癌细胞中诱导G2/M期的细胞周期停滞。在50 µM的浓度下，减少MCF-7和ZR-75-1乳腺癌细胞的增殖。Azurin (50-77)以25 µM的浓度减少VEGF-A诱导的毛细管管腔形成（IC50 = 12 µM），降低人脐静脉内皮细胞（HUVECs）中与细胞膜相关的F-actin、焦点粘附激酶（FAK）和paxillin的水平，并增加胞外的血小板内皮细胞粘附分子-1（PECAM-1）的水平。在体内，Azurin (50-77)（每日10 mg/kg）在MCF-7小鼠异种移植模型中减少肿瘤体积。

化合物

Cat.No: T4435

Synonym: ER68203-00

Target: Integrin

Cat.No: T67749

Synonym: IS-741

Target: Phospholipase

Cat.No: T70211

Cat.No: T76254

Cat.No: T76254L

Azurin (50-77) (P. aeruginosa) TFA

Cat.No: T83680

Synonym: Azurin p28,p28

Cat. No.	Product Name	Target	Signaling Pathways
T36513	Pyranonigrin A
	Pyranonigrin A is a fungal metabolite originally isolated from Aspergillus that has antioxidant activity. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH;) free radicals in a cell-free assay (IC50 = 132.9 μM). Pyranonigrin A (10 μM) suppresses TNF-α-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs).

天然产物

Cat.No: T36513

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00970	CD31/PECAM-1 Protein, Human, Recombinant (His) platelet/endothelial cell adhesion	Human	HEK293 Cells
	CD31/PECAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66 kDa and the accession number is EAW94208.1.
TMPY-02745	ESAM Protein, Rat, Recombinant (hFc) endothelial cell adhesion mol...	Rat	HEK293 Cells
	ESAM Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.2 kDa and the accession number is Q6AYD4.
TMPY-00797	ESAM Protein, Human, Recombinant (hFc) W117m,endothelial cell adhesion <...	Human	HEK293 Cells
	ESAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.5 kDa and the accession number is Q96AP7-1.
TMPY-00798	ESAM Protein, Human, Recombinant endothelial cell adhesion mol...	Human	HEK293 Cells
	ESAM Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.5 kDa and the accession number is Q96AP7-1.
TMPY-01312	ESAM Protein, Human, Recombinant (His) endothelial cell adhesion mol...	Human	HEK293 Cells
	ESAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.4 kDa and the accession number is Q96AP7-1.
TMPY-02734	ESAM Protein, Mouse, Recombinant (His) endothelial cell adhesion mol...	Mouse	HEK293 Cells
	ESAM Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is Q925F2.
TMPY-01619	CD31/PECAM-1 Protein, Mouse, Recombinant (His) Pecam,C85791,PECAM-1,Cd31,platelet/endothelial ...	Mouse	HEK293 Cells
	CD31/PECAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66 kDa and the accession number is Q03311.
TMPY-00706	CD31/PECAM-1 Protein, Human, Recombinant (hFc) GPIIA',PECA1,CD31/EndoCAM,CD31,PECAM-1,platelet/endothel...	Human	HEK293 Cells
	CD31/PECAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 91.2 kDa and the accession number is EAW94208.1.
TMPY-00707	CD31/PECAM-1 Protein, Human, Recombinant PECAM-1,CD31/EndoCAM,CD31,GPIIA',platelet/endothelial	Human	HEK293 Cells
	CD31/PECAM-1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 65.1 kDa and the accession number is EAW94208.1.
TMPJ-00382	P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated PADGEM,CD62 antigen-like family member P,Granule membrane pr...	Mouse	HEK293 Cells
	P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells. It induced expression in lung, liver, kidney and heart after endotoxin treatment. Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes...
TMPY-02292	IGSF11 Protein, Human, Recombinant (His) CT119,immunoglobulin superfamily, member 11,BT-IgSF,Igsf13,C...	Human	HEK293 Cells
	Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hep...
TMPK-00558	BCAM Protein, Cynomolgus, Recombinant (His) CD239,MSK19,Lutheran,Gplu,LU	Cynomolgus	HEK293 Cells
	Lutheran/basal cell adhesion molecule (Lu/BCAM) is a transmembrane adhesion molecule expressed by erythrocytes and endothelial cells that can interact with the extracellular matrix protein laminin-α5. In sickle cell disease, Lu/BCAM is thought to contribute to adhesion of sickle erythrocytes to the vascular wall, especially during vaso-occlusive crises.
TMPK-00562	CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His) FLJ58394,PECAM-1,GPIIA',FLJ34100,EndoCAM,PECA1,CD31	Cynomolgus	HEK293 Cells
	Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 65.30 kDa and the accession number is A0A7N9CHZ3.
TMPJ-00273	IGSF11 Protein, Human, Recombinant (hFc) CXADRL1,BT-IgSF,CT119,Igsf13,VSIG3	Human	HEK293 Cells
	Immunoglobulin superfamily member 11(IGSF11) is abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.IGSF11 functions as a cell adhesion molecule through homophilic interaction and can also stimulates cell growth.IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions.
TMPK-00834	CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His) PECAM-1,FLJ58394,GPIIA',PECA1,EndoCAM,FLJ34100,CD31	Human	HEK293 Cells
	Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 65.6 kDa and the accession number is P16284-1.
TMPJ-00930	VCAM-1 Protein, Mouse, Recombinant (hFc) Vascular cell adhesion protein 1,Vcam1	Mouse	HEK293 Cells
	Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface protein belonging to the immunoglobulin superfamily, the protein is expressed by activated endothelial cells and certain leukocytes (such as macrophages). IL-1 beta, IL-4, TNF-alpha and IFN-gamma induced the expression of VCAM-1. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. Mouse VCAM-1 is Important in cell-cell recognition. it appears to function in leukocyte-endothelial cell adhesion, and interac...
TMPK-00833	CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc) FLJ34100,EndoCAM,PECA1,PECAM-1,FLJ58394,GPIIA',CD31	Human	HEK293 Cells
	Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 91.2 kDa and the accession number is P16284-1.
TMPJ-00377	VCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated INCAM-100,Vascular cell adhesion protein 1...	Human	HEK293 Cells
	VCAM-1 (CD106, INCAM-110) is a cell adhesion molecule and a member of the immunoglobulin superfamily. It's important function is a recognition of cell-cell. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation。
TMPK-00349	E-Selectin/CD62E Protein, Human, Recombinant (His & Avi) ESEL,RP1-117P20.2,CD62E,ELAM,ELAM1,selectin E,E-Selectin,LEC...	Human	HEK293 Cells
	E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-Selectin/CD62E Protein, Human, Recombinant (His & Avi) is expressed in HEK293...
TMPK-00487	E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His) selectin E,ELAM,ESEL,SELE,E-Selectin,LECAM2,CD62E,ELAM1	Cynomolgus	HEK293 Cells
	E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His) is expressed...
TMPK-00350	E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated CD62E,ELAM,SELE,selectin E,LECAM2,ESEL,RP1-117P20.2,ELAM1,E-...	Human	HEK293 Cells
	E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated is expre...
TMPY-01484	THSD1 Protein, Mouse, Recombinant (His) 4833423O18Rik,thrombospondin type 1 domain containing 1,Tmts...	Mouse	HEK293 Cells
	Thrombospondin type-1 domain-containing protein 1, also known as transmembrane molecule with thrombospondin module, THSD1 and TMTSP, is a single-pass type I membrane protein that contains one TSP type-1 domain. THSD1 is a multi-domain, multi-functional glycoprotein synthesized by many cells. Matricellular THSD1 modulates cell adhesion and proliferation. It is involved in angiogenesis, inflammation, wound healing and cancer. In vitro, nanomolar concentrations of Thrombospondin-1 are required to a...
TMPY-03653	CTRL Protein, Human, Recombinant (His) CTRL1,chymotrypsin-like	Human	HEK293 Cells
	CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of cell adhesion molecule expressions, activation of cellular protease, and induction of extracellular regulated kinase phosphorylation. Activated microglia have been observed in variou...
TMPJ-00323	Nectin-2 Protein, Mouse, Recombinant (hFc) Herpes Virus Entry Mediator B,PVRL2,Poliovirus Receptor-Rela...	Mouse	HEK293 Cells
	CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens ju...

重组蛋白

CD31/PECAM-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00970

Species: Human

Expression System: HEK293 Cells

ESAM Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-02745

Species: Rat

Expression System: HEK293 Cells

ESAM Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00797

Species: Human

Expression System: HEK293 Cells

ESAM Protein, Human, Recombinant

Cat.No: TMPY-00798

Species: Human

Expression System: HEK293 Cells

ESAM Protein, Human, Recombinant (His)

Cat.No: TMPY-01312

Species: Human

Expression System: HEK293 Cells

ESAM Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02734

Species: Mouse

Expression System: HEK293 Cells

CD31/PECAM-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01619

Species: Mouse

Expression System: HEK293 Cells

CD31/PECAM-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00706

Species: Human

Expression System: HEK293 Cells

CD31/PECAM-1 Protein, Human, Recombinant

Cat.No: TMPY-00707

Species: Human

Expression System: HEK293 Cells

P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00382

Species: Mouse

Expression System: HEK293 Cells

IGSF11 Protein, Human, Recombinant (His)

Cat.No: TMPY-02292

Species: Human

Expression System: HEK293 Cells

BCAM Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00558

Species: Cynomolgus

Expression System: HEK293 Cells

CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00562

Species: Cynomolgus

Expression System: HEK293 Cells

IGSF11 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00273

Species: Human

Expression System: HEK293 Cells

CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His)

Cat.No: TMPK-00834

Species: Human

Expression System: HEK293 Cells

VCAM-1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00930

Species: Mouse

Expression System: HEK293 Cells

CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc)

Cat.No: TMPK-00833

Species: Human

Expression System: HEK293 Cells

VCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00377

Species: Human

Expression System: HEK293 Cells

E-Selectin/CD62E Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00349

Species: Human

Expression System: HEK293 Cells

E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His)

Cat.No: TMPK-00487

Species: Cynomolgus

Expression System: HEK293 Cells

E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00350

Species: Human

Expression System: HEK293 Cells

THSD1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01484

Species: Mouse

Expression System: HEK293 Cells

CTRL Protein, Human, Recombinant (His)

Cat.No: TMPY-03653

Species: Human

Expression System: HEK293 Cells

Nectin-2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00323

Species: Mouse

Expression System: HEK293 Cells

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